The INS was developed by the Codex Alimentarius Commission — a joint program of the Food and Agriculture Organization (FAO) and the World Health Organization (WHO) — to provide a unified international system for identifying food additives. The system is published in the Codex Alimentarius's "Class Names and the International Numbering System for Food Additives" (CXS 192-1995).
The INS assigns a unique number to each food additive, organized by functional category. The numbers are broadly aligned with the European E-number system — for example, INS 202 and E202 both refer to potassium sorbate. However, the INS does not use the "E" prefix and includes some additives that may not be approved for use in the European Union. The INS serves as a reference numbering system; it does not itself authorize additives for use in any country.
While the INS and E-number systems are closely related, there are important distinctions that consumers and food professionals should understand:
| Feature | INS Numbers | E-Numbers |
|---|---|---|
| Origin | Codex Alimentarius (FAO/WHO) | European Union (EFSA) |
| Scope | International (global reference) | European Union only |
| Prefix | None (just the number, e.g., "202") | "E" prefix (e.g., "E202") |
| Authorization | Does not authorize use in any country | Indicates EU approval for use |
| Numbering | Same numbering scheme as E-numbers | Same numbering scheme as INS |
| Additional entries | Includes some additives not in EU system | Includes only EU-approved additives |
| Labeling | Used in some countries' food labels | Required on EU food labels |
| Maintenance | Updated by Codex Committee on Food Additives | Updated by European Commission |
A key principle to remember: all E-numbers have corresponding INS numbers, but not all INS numbers have E-number equivalents. An additive may have an INS number but not be approved for food use in the EU, meaning it would not have an E-number.
The INS organizes additives by functional category, using the same numbering ranges as the E-number system:
| INS Range | Category | Function | Examples (INS / E-Number) |
|---|---|---|---|
| 100–199 | Food Colors | Add or restore color | INS 100 / E100 (Curcumin), INS 120 / E120 (Carmine) |
| 200–299 | Preservatives | Prevent microbial growth, extend shelf life | INS 202 / E202 (Potassium sorbate), INS 211 / E211 (Sodium benzoate) |
| 300–399 | Antioxidants & Acidity Regulators | Prevent oxidation, control pH | INS 300 / E300 (Ascorbic acid), INS 330 / E330 (Citric acid) |
| 400–499 | Thickeners, Stabilizers, Emulsifiers | Modify texture and consistency | INS 407 / E407 (Carrageenan), INS 412 / E412 (Guar gum) |
| 500–599 | Acidity Regulators & Anti-caking Agents | Control pH, prevent clumping | INS 500 / E500 (Sodium carbonate) |
| 600–699 | Flavor Enhancers | Intensify taste and aroma | INS 621 / E621 (MSG), INS 631 / E631 (Disodium inosinate) |
| 700–899 | Reserved / Feed Additives | Various | Limited food use |
| 900–999 | Sweeteners, Glazing Agents | Sugar substitutes, surface treatment | INS 951 / E951 (Aspartame), INS 955 / E955 (Sucralose) |
| 1000+ | Additional Additives | Specialized functions | INS 1100 / E1100 (Amylases), INS 1200 / E1200 (Polydextrose) |
| INS Number | E-Number | Additive Name | Source | ADI (mg/kg bw/day) |
|---|---|---|---|---|
| 100 | E100 | Curcumin | Natural (turmeric) | 0–3 |
| 101 | E101 | Riboflavin | Natural/synthetic | 0–0.5 |
| 102 | E102 | Tartrazine | Synthetic | 0–7.5 |
| 110 | E110 | Sunset Yellow FCF | Synthetic | 0–3.75 |
| 120 | E120 | Cochineal/Carmine | Natural (insect) | 0–5 |
| 129 | E129 | Allura Red AC | Synthetic | 0–7 |
| 133 | E133 | Brilliant Blue FCF | Synthetic | 0–6 |
| 140 | E140 | Chlorophyll | Natural (plants) | Not specified |
| 160a | E160a | Beta-carotene | Natural/synthetic | 0–5 (temp.) |
| 160b | E160b | Annatto | Natural (achiote) | Pending |
| 160c | E160c | Paprika extract | Natural (paprika) | Not specified |
| 162 | E162 | Beetroot red | Natural (beetroot) | Not specified |
| 163 | E163 | Anthocyanins | Natural (grapes, berries) | Not specified |
| 171 | E171 | Titanium dioxide | Mineral-derived | 0–10 (temp., EU banned) |
| 150d | E150d | Caramel (Class IV) | Processed sugar | 0–200 (group) |
| INS Number | E-Number | Additive Name | ADI (mg/kg bw/day) |
|---|---|---|---|
| 200 | E200 | Sorbic acid | 0–25 |
| 202 | E202 | Potassium sorbate | 0–25 |
| 211 | E211 | Sodium benzoate | 0–5 |
| 220 | E220 | Sulfur dioxide | 0–0.7 (group) |
| 221 | E221 | Sodium sulfite | 0–0.7 (group) |
| 224 | E224 | Potassium metabisulfite | 0–0.7 (group) |
| 234 | E234 | Nisin | 0–0.13 (temp.) |
| 235 | E235 | Natamycin | 0–0.3 |
| 249 | E249 | Potassium nitrite | 0–0.07 |
| 250 | E250 | Sodium nitrite | 0–0.07 |
| 251 | E251 | Sodium nitrate | 0–3.7 |
| 280 | E280 | Propionic acid | Not limited |
| 282 | E282 | Calcium propionate | Not limited |
| INS Number | E-Number | Additive Name | Category | ADI (mg/kg bw/day) |
|---|---|---|---|---|
| 300 | E300 | Ascorbic acid (Vitamin C) | Antioxidant | Not specified |
| 306 | E306 | Tocopherols (Vitamin E) | Antioxidant | 0.15–2 |
| 310 | E310 | Propyl gallate | Antioxidant | 0–1.4 |
| 320 | E320 | BHA | Antioxidant | 0–0.5 |
| 321 | E321 | BHT | Antioxidant | 0–0.3 |
| 322 | E322 | Lecithin | Emulsifier | Not specified |
| 330 | E330 | Citric acid | Acidity regulator | Not limited |
| 392 | E392 | Rosemary extract | Antioxidant | Not specified |
| 407 | E407 | Carrageenan | Thickener/emulsifier | 0–75 |
| 410 | E410 | Locust bean gum | Thickener | Not specified |
| 412 | E412 | Guar gum | Thickener | Not specified |
| 414 | E414 | Gum arabic | Emulsifier/thickener | Not specified |
| 415 | E415 | Xanthan gum | Thickener | Not specified |
| 433 | E433 | Polysorbate 80 | Emulsifier | 0–10 |
| 440 | E440 | Pectin | Gelling agent | Not specified |
| 466 | E466 | Carboxymethylcellulose | Emulsifier | 0–25 |
| 471 | E471 | Mono- and diglycerides | Emulsifier | Not specified |
| INS Number | E-Number | Additive Name | Category | ADI (mg/kg bw/day) |
|---|---|---|---|---|
| 621 | E621 | Monosodium glutamate (MSG) | Flavor enhancer | 0–30 (group) |
| 627 | E627 | Disodium guanylate | Flavor enhancer | Not specified |
| 631 | E631 | Disodium inosinate | Flavor enhancer | Not specified |
| 950 | E950 | Acesulfame K | Sweetener | 0–9 |
| 951 | E951 | Aspartame | Sweetener | 0–40 |
| 952 | E952 | Cyclamates | Sweetener | 0–7 |
| 954 | E954 | Saccharin | Sweetener | 0–5 |
| 955 | E955 | Sucralose | Sweetener | 0–15 |
| 960 | E960 | Steviol glycosides (Stevia) | Sweetener | 0–4 |
| 967 | E967 | Xylitol | Sweetener | Not specified |
| 968 | E968 | Erythritol | Sweetener | Not specified |
The INS serves as the international reference, but countries implement it differently in their food labeling regulations:
EU food labels use E-numbers, which are derived from the INS. All EU-approved food additives have E-numbers. The EU maintains a positive list (Annex II of Regulation 1333/2008) of authorized additives with their E-numbers, permitted food categories, and maximum levels.
The FDA does not use the INS or E-number system on food labels. Additives are listed by their common or usual name (e.g., "monosodium glutamate" rather than "INS 621" or "E621"). Colors are listed as "FD&C Yellow No. 5" or similar. However, the FDA's regulatory framework is compatible with the INS at a technical level, and the same additives are generally permitted.
Japan maintains its own additive coding system but largely aligns with the INS. Japanese food labels may use additive names rather than numbers. Japan has a positive list system (like the EU) rather than a GRAS system (like the US).
Food Standards Australia New Zealand (FSANZ) uses INS numbers on food labels, typically without the "E" prefix. Labels may show the additive name and/or the INS number in parentheses.
China uses a national standard (GB 2760) that references the INS. Chinese food labels may include INS numbers or additive names in Chinese.
India's Food Safety and Standards Authority (FSSAI) uses INS numbers for food additive identification, consistent with Codex Alimentarius standards.
The Codex Alimentarius Commission was established in 1963 by the FAO and WHO to develop international food standards, guidelines, and codes of practice. The General Standard for Food Additives (GSFA, CXS 192-1995) is the Codex reference document that lists all INS-numbered additives, their permitted uses, and maximum levels in specific food categories.
Codex standards serve as the reference for international food trade under the World Trade Organization's Sanitary and Phytosanitary (SPS) Agreement. When countries dispute food safety measures that affect trade, Codex standards are used as the benchmark. This makes the INS system critically important for international food commerce — a manufacturer exporting to multiple countries must ensure compliance with each destination's regulations, all of which are ultimately referenced to the INS.
The Joint FAO/WHO Expert Committee on Food Additives (JECFA) provides independent scientific advice on food additives. JECFA evaluates the safety of additives and establishes ADI values that are used as reference points by regulatory agencies worldwide. JECFA's evaluations feed into Codex standards and the INS.
While EFSA (EU), FDA (US), and JECFA (international) often reach similar conclusions, they sometimes differ. For example, JECFA established an ADI of 0–40 mg/kg bw/day for aspartame, while EFSA set the same value but the FDA's acceptable daily intake is 50 mg/kg bw/day. These differences reflect variations in how each body interprets scientific data and applies safety factors.
For consumers, the INS system provides a way to identify additives regardless of the country where a food product was manufactured. Here's how to use INS numbers effectively:
Some additives have been assigned INS numbers by Codex but are not approved in the EU, meaning they lack E-numbers. These include:
Consumers encountering an unfamiliar INS number should use our Food Additive Safety Checker to determine whether it corresponds to an E-number and what its safety profile is.
Medical Disclaimer: The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider or pharmacist before making any decisions about medications, supplements, or treatments. Never disregard professional medical advice because of something you read here.